The Doofenshmirtz family is a family originally from Drusselstein. The first confirmed member is the evil Dr. Jekyll Doofenshmirtz from the Victorian days, although it is highly probable that Doofus Khan from ("Doof Dynasty") is related to the Doofenshmirtz family, (and if so they would be older) this is unconfirmed.
Fluffy Pants Doofenshmirtz
- "Spa Day"
Heinz Doofenshmirtz's unnamed mother
Professor Von Doofenshmirtz
- Attack of the 50 Foot Sister (Mentioned only)
- Druselsteinoween (mentioned)
- In the Russian dub of the series, the name was changed to Foofelsmirz (Фуфелшмерц).