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Gretel Doofenshmirtz
Gretel Doofenshmirtz up close
Gender: Female
Age: Unknown (presumably deceased)
Nationality: Drusselsteinian (presumably)
Professional Information
Affiliations:
  Doofenshmirtz family
Friends and Family
Children:
José Doofenshmirtz
Grandchildren:
Mr. Doofenshmirtz
Fluffy Pants Doofenshmirtz
Great-grandchildren:
Heinz Doofenshmirtz
Roger Doofenshmirtz
Great-great-grandchildren:
Vanessa Doofenshmirtz
Granddaughter-in-law:
Mrs. Doofenshmirtz
Father-in-law:
Jekyll Doofenshmirtz
Behind the Scenes
First Appearance:
  "Meatloaf Surprise"
Last Appearance:
  "Meatloaf Surprise"

Gretel Doofenshmirtz was Heinz Doofenshmirtz's great-grandmother who was a great cook, specifically in creating a meatloaf recipe with the secret ingredient of "Hate". She passed it onto her son: José Doofenshmirtz who passed it on to Heinz Doofenshmirtz's mother who passed it onto Roger Doofenshmirtz. Heinz then stole it ("Meatloaf Surprise"). According to Heinz Doofenshmirtz, Great-Grandma Gretel had "Issues". Heinz might've known his great-grandmother personally since he said that she had "Issues" as if he knew what they were. Of course, it is possible that he was told this by his Grandpa José or his parents.