At the age of 17, she rebelled against the Pentecostal church. In her late teens, she started singing old gospel tunes, and entered the world of stand-up comedy on the advice of a close friend. In her comedy routine, DeLisle imitated voices very well, and was advised to take a shot at voice acting.
DeLisle was first married to Christopher DeLisle in 1992 at age 19. She took his surname and changed hers from Oosbree to DeLisle. They divorced in 1993. In 2002, she married Murray Hammond of the Old 97s. She gave birth to their first child: a son named Jefferson Texas "Tex" Hammond. They divorced in 2010. DeLisle dated Jared Griffin after her divorce and they married on June 27, 2012.
The image gallery for Grey Griffin may be viewed here.