Isabella was born in Atlanta, Georgia and later relocated to Los Angeles. She has a younger sister, Ava, who is also an actress.
Isabella's first acting role was on the USA Network series, Monk. She has also guest starred on The Mentalist, Hannah Montana, Desperate Housewives, The Middle, and The Event. She provided voice-over and ADR work on television shows such as Scooby Doo! Mystery Incorporated and Adventure Time, and movies such as Air Buddies, 30 Days of Night, Horton Hears a Who!, The Women, Four Christmases, Cloudy With a Chance of Meatballs, A Nightmare on Elm Street, The Back-Up Plan, Hereafter, How Do You Know, Yogi Bear, Little Fockers, The Last Airbender, and Free Willy: Escape from Pirate's Cove.
Isabella starred in the 2011 television movie, Beyond the Blackboard and will star in the upcoming film, The Future. She has also starred in commercials for Wal Mart, El Pollo Loco, Mrs. Butterworth, Children's Claritin medicine, McDonald's Littlest Pet Shop Happy Meal, and Keebler Cookies.
Isabella is also best known for her role as Rose Crisp on the ABC comedy series, "Better Off Ted" which aired from March 2009 to January 2010.
- 2009 Young Artists Awards nomination for "Best Performance in a TV Series, Guest Starring Young Actress" (For her guest-starring role in "The Mentalist")
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