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Main Street is a street in Danville. It has been named in "Dude, We're Getting the Band Back Together", "It's a Mud, Mud, Mud, Mud World", and Phineas and Ferb The Movie: Across the 2nd Dimension. It is the location of Danny's Music Shop and Doofenshmirtz Evil Incorporated.
During the Ferb-Latin craze, streets signs were changed to read "Ain-Merb Eet-Strerb" ("Ferb Latin").
There is apparently a creepy guy on 3rd St and Main. ("Bee Story")