The Ugly-inator, was a device that turned whatever it shot ugly. Its use can be reversed by inserting an object that is considered "beautiful" (such as a picture of Vance Ward). Dr. Doofenshmirtz intended to fire it at all of the handsome people in the Tri-State Area in order to make himself look handsome by comparison, but Perry the Platypus expectantly thwarted his scheme.
- Perry the Platypus: Became ugly enough for Doofenshmirtz to laugh.
- Heinz Doofenshmirtz: Humorously, he was already ugly so the ray had no effect.
- The Audience: Became a punk audience.
- Jeremy and the Incidentals: Became a Punk/Death Metal Band.
- Vance Ward: Went bald, hairy and deformed; clothes and suit were replaced with underwear and tank-top.
- Heinz's Big-Screen T.V.: Became an older 70's-style CRT TV.
- Heinz's Recliner: Became a plastic lawn chair.
- Heinz's Balloon: (Used when the effects of the weapon were reversed) became cute and girly.
- Dr. Doofenshmirtz invents a De-Handsome-Inator ("Quietest Day Ever"), which should be similar to the Ugly-inator.