The first letter in her name is an upside down M, the first letter of "Monogram." Also, "Acronym" and "Monogram" both describe a group of initials.
She talks in a British accent and has met Perry.
Much like Monogram, she has an intern. Her intern is named Carla and it is implied that she is related to Carl in some way, since Acronym states that she "comes from an entire family of unpaid interns".
In "Phineas and Ferb Save Summer", the O.W.C.A. was declared to be shut down because of its budget going over thanks to a ballroom fiasco. However, Major Monogram suggested that he just create a new O.W.C.A. and fires his superior in order to keep costs down on leadership. It is unknown if Admiral Acronym is affected by this, either she would be fired because of the original agency shutdown or she would go on to join in Monogram's new agency to keep her job.
Admiral Acronym was first referred to as Wanda, her first name. Until Bee Story, her "code name" was not revealed.